Differential response of gel-forming mucins to pathogenic middle ear bacteria
نویسندگان
چکیده
منابع مشابه
Middle Ear Response of Muc5ac and Muc5b Mucins to Nontypeable Haemophilus influenzae.
IMPORTANCE Chronic otitis media with effusion is characterized by middle ear secretion of mucin glycoproteins, predominantly MUC5B; MUC5AC, the other secretory mucin studied frequently, has also been identified in the middle ear. Emerging evidence suggests a dichotomous role for these mucins in innate immune responses. We hypothesized that MUC5AC is an acute responder and MUC5B is expressed at ...
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Mucins are important glycoproteins in the mucociliary transport system of the middle ear and Eustachian tube. Little is known about mucin expression within this system under physiological and pathological conditions. This study demonstrated the expression of MUC5B, MUC5AC, MUC4, and MUC1 in the human Eustachian tube, whereas only MUC5B mucin expression was demonstrated in noninflamed middle ear...
متن کاملGel-forming mucins form distinct morphologic structures in airways.
Gel-forming mucins, the primary macromolecular components of airway mucus, facilitate airway clearance by mucociliary transport. In cystic fibrosis (CF) altered mucus properties impair mucociliary transport. Airways primarily secrete two closely related gel-forming mucins, MUC5B and MUC5AC. However, their morphologic structures and associations in airways that contain abundant submucosal glands...
متن کاملGel-forming mucins. Notions from in vitro studies.
Mucus secretions form a protective barrier in the mucosa of the auditory, gastrointestinal, respiratory, and urogenital systems, and the conjunctiva in the eyes. A family of glycoproteins known as gel forming mucins is the major component of the mucus. Gel-forming mucins are among the largest and most complex proteins known. Their polypeptide chains comprise thousands of amino acid residues org...
متن کاملSubmaxillary mucins. Intermolecular interactions and gel-forming potential of concentrated solutions.
The intermolecular interactions in concentrated solutions of pig submaxillary mucin (PSM) and sheep submaxillary mucin (SSM) were studied by mechanical spectroscopy. PSM and SSM were purified from detectable protein and nucleic acid by equilibrium centrifugation in a CsCl density gradient. PSM and SSM isolated in the presence of proteinase inhibitors showed distinct differences from preparation...
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ژورنال
عنوان ژورنال: International Journal of Pediatric Otorhinolaryngology
سال: 2014
ISSN: 0165-5876
DOI: 10.1016/j.ijporl.2014.05.037